Flex Updates | Period & Health Research: October 2020

Flex Updates | Period & Health Research: October 2020

Flex Updates | Period & Health Research: October 2020

TL/DR: Here’s what’s new in reproductive health research as of October 2020: Researchers have found that estrogen and progesterone may be protective against COVID-19; the diabetic drug metformin may be helpful for PCOS patients struggling with infertility; a new treatment may offer relief for uterine fibroids.

Here at Flex, we’re constantly checking in with our team of reproductive health experts and OB-GYNs to find out what’s new on the medical scene – asking about everything from recently published research to cutting-edge treatments and therapies for conditions like endometriosis, uterine fibroids, PCOS, and infertility. We think it’s so important to keep our staff and our customers up-to-date on critical developments, especially the ones that have the potential to majorly impact our lives. 

That’s why we’re excited to introduce a new blog series, “Updates in Reproductive Health Research,” to give our readers a quick monthly roundup of the news, stats, and advancements impacting the industry right now. This month’s update, compiled by MD-MPH candidate and Flex medical reviewer Jahnavi Curlin, covers some interesting hormone-related developments in COVID-19 research, a newly approved therapy for uterine fibroids, and findings re: a drug that may help PCOS patients trying to get pregnant via IVF. Let’s dive in: 


A Hormone-Based Treatment Approach to COVID-19

This month’s edition of industry updates couldn’t begin without addressing the elephant in the room: COVID-19. As a brief reminder (in case you haven’t been glued to your phone for the last seven months like we have), COVID-19 is the disease caused by the novel coronavirus, SARS-COV-2. As of October 1, the disease has infected more than 35 million and led to the death of 1.04 million people around the globe.

While pharmaceutical companies are scrambling to launch an effective vaccine by early 2021, there’s still much debate around when such a vaccine could become widely available. Meanwhile, thousands of other medical researchers have been working on a treatment for patients already infected with the virus: While no treatment has been officially released, the FDA has (as recently as August 23rd) approved several therapies, including the drug remdesivir, for emergency use in advanced cases (1).

However, there is another potentially viable treatment being tossed around in scientific circles that’s made it as far as two clinical trials (now taking place in New York). This treatment may sound familiar to you, Flex readers: it’s none other than the pair of hormones that drive your monthly cycle, estrogen and progesterone.

While we’re still learning more about this virus in real time, researchers at Tulane found that  COVID-19 patients assigned female at birth had less severe disease and better recovery outcomes than those assigned male (2). Why? Because estrogen and progesterone have been found to calm down COVID-19’s damaging “cytokine storm.

The long and the short of what we know is that estradiol (a form of estrogen) and progesterone have hardcore anti-inflammatory properties. One of the things that they can do is reduce the number of interleukins in your bloodstream. Interleukins are basically the “first responders” of your immune system, and interleukin-6 (IL-6), in particular, is one of the major components of the cytokine storm that makes COVID-19 so deadly.

Researchers are continuing to study the potential benefit of estradiol and progesterone hormone therapy on COVID-19 patients. One benefit to this treatment approach is the wealth of knowledge scientists already have about the pharmacology, dosages, and potential toxicity of hormone therapy – making it easier to speed up off-label use in potentially life-threatening cases of the virus (2). We’ll continue to keep an eye on the research and provide an update should this treatment be approved by the FDA.


A New Option for Individuals with PCOS Undergoing Fertility Challenges

In other news, for individuals diagnosed with polycystic ovary syndrome (PCOS), new research suggests that the drug metformin may be helpful for IVF-assisted pregnancy for certain groups of people​. Some background: PCOS is a hormonal disease that tends to cause infrequent or absent menstrual cycles. When those with PCOS do get a period, it may be especially painful or heavy –  and show up totally unannounced.

Periods aren’t the only challenge faced by individuals with PCOS (though we hope to have made them  a little bit easier with the Flex disc, which has been shown to reduce cramps and can be worn for longer periods of time than traditional menstrual products, even on heavy days). Many people with PCOS have difficulty becoming pregnant because they ovulate irregularly. As a result, many turn to therapies such as in-vitro fertilization (IVF)

A recent study found that individuals with PCOS who took metformin while pursuing IVF had an overall decrease in something called ovarian hyperstimulation syndrome, which is a painful and potentially harmful condition that happens when taking the extra hormones during IVF (3). And, interestingly enough, the group of individuals given metformin  (and who had a BMI greater than 26) were associated with a significantly ​greater c​linical pregnancy rate (e.g., more women became pregnant while on the drug).

For reference, metformin is an oral medication that is often prescribed for diabetes. It works by decreasing glucose production while simultaneously increasing the amount of glucose used by the body, netting out to a lower overall glucose or blood sugar level.

The science behind why a medication designed for diabetes seems to improve fertility for PCOS patients undergoing IVF is complex – these findings do, however, have the potential to significantly impact the fertility prognosis for individuals with PCOS. It’s something to consider asking your OB-GYN or healthcare provider about, especially if you match these criteria: Diagnosed with PCOS, BMI of 26 or higher, and seeking pregnancy through IVF.


Oriahnn for Uterine Fibroids

Finally, a promising new treatment for uterine fibroids was recently approved by the FDA​.

FYI, uterine fibroids are non-cancerous growths that develop in the uterus, often leading to symptoms like pain in your nether regions or long,heavy periods. While many Flex users with fibroids have had a lot of success dealing with their periods by switching to Flex discs or the Flex cup (the Slim Fit holds the equivalent of 2 super tampons; the Full Fit holds 3 super tampons’ worth of period blood), heavy bleeding can still be a major pain, getting in the way of day-to-day activities.

If you’ve been searching for another way to manage bleeding caused by uterine fibroids, you may be in luck: A new drug called Oriahnn was just approved by the FDA (4). It’s a combination product containing one pill with  elagolix, estradiol, and norethindrone acetate  (taken in the morning) and another pill with only elagolix (taken in the evening).  As a whole, Oriahnn can be taken for up to 2 years.

Clinical studies showed that the majority of patients (68.5% in the first study, 76.5% in the second study) on this drug had a 50% decrease in menstrual blood loss at the end of the study compared to the beginning. In addition, participants' final menstrual period during the study had blood loss of less than 80 mL (where 80 mL and above is the clinical definition of a heavy menstrual period).

To summarize this long list of numbers, the drug was associated with a lighter menstrual flow for women in both clinical trials – a finding that could have an incredible impact on quality of life for women with uterine fibroids. Oriahnn joins the list of other, existing treatments for uterine fibroids, including hormonal birth control and surgery.



  1. United States Food and Drug Administration. (September 2020). Investigational COVID-19 Convalescent Plasma - Emergency INDs. Retrieved from fda.gov/vaccines-blood-biologics/investigational-new-drug-ind-or-device-exemption-ide-process-cber/recommendations-investigational-covid-19-convalescent-plasma.
  2. Mauvais-Jarvis, F., Klein, S. L., & Levin, E. R. (2020). Estradiol, Progesterone, Immunomodulation, and COVID-19 Outcomes. Endocrinology, 161(9). doi:10.1210/endocr/bqaa127. Retrieved from academic.oup.com/endo/article/161/9/bqaa127/5879027.
  3. Wu, Y., Tu, M., Huang, Y., Liu, Y., & Zhang, D. (2020). Association of Metformin With Pregnancy Outcomes in Women With Polycystic Ovarian Syndrome Undergoing In Vitro Fertilization. JAMA Network Open, 3(8). doi:10.1001/jamanetworkopen.2020.11995. Retrieved from ncbi.nlm.nih.gov/pmc/articles/PMC7399751/.
  4. Voelker, R. (2020). Relief From Heavy Bleeding Due to Uterine Fibroids. JAMA, 324(1), 19. doi:10.1001/jama.2020.11456.


Writer: Jahnavi Curlin, MD-MPH candidate and women's health aficionado. Find her on Twitter @jahnavi_curlin and at her website, curlincommunications.com.


  • Your period
  • Your lifestyle
  • Your concerns

Typically, how many days is your period?

How heavy is your flow on your heaviest days?

When did your last period start?

How many weeks do you typically have between periods?

What period product do you use most frequently?

How disruptive can your period be to your life?

What bothers you most about having your period?

What is the one thing you wish you could change about your period?

  • < 2 Days
  • 3 Days
  • 4 Days
  • 5 Days
  • 6 Days
  • 7 Days
  • > 8 Days
LIGHT (1-2 tampons/day)
MEDIUM (3-4 tampons/day)
HEAVY (4-5 tampons/day)
  • < 2 Weeks
  • 3 Weeks
  • 4 Weeks
  • 5 Weeks
  • 6 Weeks
  • 7 Weeks
  • > 8 Weeks
Tampon Tampons
Pad Pads
Menstrual Cup Cup
Menstrual Disc Discs
Period Panties Period Panties
Ellipses Others
Can’t get out of bed
Can’t do certain activities
I mostly feel uncomfortable
Just like any other day
I’m constantly running to the bathroom
I can’t sleep through the night
My work out routine is thrown off
I can’t have sex
I feel uncomfortable
Less cramping
Less odor
Fewer leaks
Risk of TSS
Less waste
If you’re not sure, choose MEDIUM.

All done!

What email would you like your results sent to?

By clicking "See My Results" you agree to
receive email from The Flex Company.

Here is our pick for you!
Flex Box
plan type
Light plan $6.50
4 Discs per cycle per period
8 Discs every 2 months
Light Flow Starter Kit
Includes 8 discs + our Getting Started Guide

We will automatically ship 8 discs for $12.99 every two months starting on . We’ll remind you before we process the next order. You can pause or cancel anytime, online.

Flex Box
plan type
Medium plan $12
8 Discs per cycle per period
16 Discs every 2 months
Medium Flow Starter Kit
Includes 8 discs + our Getting Started Guide

We will automatically ship 16 discs for $23.99 every one month starting on . We’ll remind you before we process the next order. You can pause or cancel anytime, online.

Flex Box
plan type
Heavy plan $14
Discs per cycle per period
24 Discs every 2 months
Heavy Flow Starter Kit
Includes 12 discs + our Getting Started Guide

We will automatically ship 24 discs for $27.99 every one month starting on . We’ll remind you before we process the next order. You can pause or cancel anytime, online.

Try FLEX with some liners at first.

Sometimes you just feel better with a little backup. FLEX plus liners would be a great combination for you while you transition to FLEX to help guard against leaks until you get the hang of positioning FLEX.

Not ready for membership? Try just one FLEX.

Here is our pick for you

Flexcup Discovery Kit
Flexcup Discovery Kit


$32.99 71+ Reviews

1 Menstrual Cup

  • + 1 Carrying Pouch
  • + 2 free Menstrual Discs

The FLEX Cup comes with 2 free FLEX Discs for you to try so that you can experience two new and innovative period products for no extra charge.

Free US Shipping

No Image